Panel cites need for individualized, patient-centered approach for chronic pain

“Persons living with have often been grouped into a single category, and treatment approaches have been generalized with little evidence to support this practice,” said Dr. David B. Reuben, panel chair and professor of medicine at the David Geffen School of Medicine at the University of California, Los Angeles. “Chronic pain spans a multitude of conditions, presents in different ways, and requires an individualized, multifaceted approach.”

http://medicalxpress.com/news/2015-01-panel-cites-individualized-patient-centered-approach.html

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A Combination of Celecoxib and Famciclovir Is Efficacious in the Treatment of Fibromyalgia: Results of a Phase IIa Randomized, Double-Blind, Placebo-Controlled Study – ACR Abstracts

It is known that infections and other types of stressors are capable of triggering the development of FM.  We hypothesize that these stressors could be responsible for triggering a reactivation of latent herpesviruses, and that this reactivation could in turn lead to the central nervous system dysregulation seen in this condition.    The present study was designed to evaluate an anti-viral drug combination selected for activity against herpes class viruses.

http://acrabstracts.org/abstracts/a-combination-of-celecoxib-and-famciclovir-is-efficacious-in-the-treatment-of-fibromyalgia-results-of-a-phase-iia-randomized-double-blind-placebo-controlled-study/

Background to this study is on http://simmaronresearch.com/2013/12/big-antiviral-trial-era-fibromyalgia/

 

Imaging study finds first evidence of neuroinflammation in brains of chronic pain patients

Imaging study finds first evidence of neuroinflammation in brains of chronic pain patients

A new study from Massachusetts General Hospital (MGH) investigators has found, for the first time, evidence of neuroinflammation in key regions of the brains of patients with chronic pain. By showing that levels of an inflammation-linked protein are elevated in regions known to be involved in the transmission of pain, the study published online in the journal Brain paves the way for the exploration of potential new treatment strategies and identifies a possible way around one of the most frustrating limitations in the study and treatment of chronic pain – the lack of an objective way to measure the presence or intensity of pain.

http://medicalxpress.com/news/2015-01-imaging-evidence-neuroinflammation-brains-chronic.html?utm_source=nwletter&utm_medium=email&utm_content=splt-item&utm_campaign=daily-nwletter

A new study led by the University of Colorado Boulder finds that when we use our thoughts to dull or enhance our experience of , the physical pain signal in the brain—sent by nerves in the area of a wound, for example, and encoded in multiple regions in the cerebrum—does not actually change. Instead the act of using thoughts to modulate pain, a technique called “cognitive self-regulation” that is commonly used to manage , works via a separate pathway in the brain.

The findings, published in the journal PLOS Biology this month, show that the processing of pain in our brains goes beyond the mere physical pain signal and underscore a growing understanding among neuroscientists that there is not a single pain system in the brain, as was once believed.

http://medicalxpress.com/news/2015-01-pain-multiple-brain-pathways.html?utm_source=nwletter&utm_medium=email&utm_content=ctgr-item&utm_campaign=daily-nwletter

Researchers discover new ‘trick’ steroids use to suppress inflammation

A new “trick” steroids use to suppress inflammation, which could be used to make new anti-inflammatory drugs without the harmful side effects of steroids, has been discovered by researchers at Georgia State University.

 

Their findings have been published in the journal Nature Communications.

http://medicalxpress.com/news/2015-01-steroids-suppress-inflammation.html?utm_source=nwletter&utm_medium=email&utm_content=splt-item&utm_campaign=daily-nwletter

“There is a need for increased awareness of suicide risk in individuals with certain noncancer pain diagnoses, in particular back pain, migraine, and psychogenic pain,” the study concludes”

JAMA Psychiatry. Published online May 22, 2013. doi:10.1001/jamapsychiatry.2013.908

http://www.medicalnewstoday.com/releases/260954.php#

Researchers at McGill University have discovered a mechanism that embeds the memory of an injury in the way the DNA is marked in the brain by a chemical coating called methyl groups or DNA methylation. The researchers report in the journal PLOS One, that if the symptoms of chronic pain are attenuated, the abnormal changes in DNA methylation could be reversed.

Chronic Pain Alters DNA Marking In The Brain